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Winter 2020, Vol. 28 No. 4

Hong Kong J. Dermatol. Venereol. (2020) 28, 149-158


Original Article

Paraneoplastic dermatomyositis accompanying nasopharyngeal carcinoma: a systematic review and meta-analysis

鼻咽癌相關的腫瘤伴生皮肌炎:系統性文獻回顧和統合分析

X Liang 梁璽, T Zhao 趙天赫, J Liu 劉建新, Z Hu 胡振彪, J He 何建明

Abstract

This systematic review and meta-analysis investigated the prognostic value of paraneoplastic dermatomyositis on the survival of patients with nasopharyngeal carcinoma (NPC). The combined hazard ratio (HR) is 1.43 [95% confidence interval (CI):0.98-2.10, p:0.06]. There was a decreased 3-year survival in NPC cases with dermatomyositis [risk ratio (RR):0.86, 95% CI:0.74-1.01, p:0.07; risk difference (RD):-0.11, 95% CI:-0.22-0.01, p:0.06] although it was not significantly associated with 5-year survival (RR:0.89, 95% CI:0.71-1.13, p:0.34; RD:0.06, 95% CI:-0.19-0.07, p:0.34). All reported NPC cases accompanying paraneoplastic syndrome were type II non-keratinising carcinomas.

本系統性文獻回顧和統合分析研究了腫瘤伴生皮肌炎伴對鼻咽癌患者存活的預後價值。綜合危險比為1.43 [95% CI:0.98-2.10, p:0.06],當中可見皮肌炎降低了鼻咽癌患者的三年生存期[RR:0.86, 95% CI:0.74-1.01, p:0.07; RD:-0.11, 95% CI:-0.22-0.01, p:0.06],但與五年生存率無明顯關聯(RR:0.89, 95% CI:0.71-1.13, p:0.34; RD:0.06, 95% CI:-0.19-0.07, p:0.34)。文獻回顧中所有伴隨副腫瘤綜合徵的鼻咽癌病例均為第二型非角化癌。

Keywords: Corticosteroids, dermatomyositis, nasopharyngeal carcinoma, prognosis

關鍵詞: 皮質類固醇、皮肌炎、鼻咽癌、預後