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Winter 2020, Vol. 28 No. 4

Hong Kong J. Dermatol. Venereol. (2020) 28, 141-148


Original Article

Comparison of the efficacy and safety of topical 4% hydroquinone cream vs topical 10% glutathione plus 5% ascorbic acid cream in patients with epidermal melasma

局部4%對苯二酚乳膏與局部10%穀胱甘肽加5%抗壞血酸乳膏在表皮黃褐斑患者中的療效和安全性比較

S Hamayun, G Butt, Z Rani, T Manzoor, M Uzair, B Bashir

Abstract

Objectives: This study compared the efficacy and safety of topical 4% hydroquinone cream vs topical 10% glutathione plus 5% Ascorbic acid cream in patients of epidermal melasma. Method: This was a randomized controlled trial in which seventy patients were enrolled according to inclusion criteria and randomly divided into two groups containing thirty-five patients in each group. The patients in Group A were given topical 4% hydroquinone cream daily at night while those in Group B were given combination of topical 10% glutathione plus 5% ascorbic acid cream daily at same time. Treatment was continued for sixteen weeks and follow up done for eight weeks after last treatment. Efficacy was assessed at the end after twenty-four weeks. Side effects were observed on every visit. Results: The mean reduction in Melasma Area Severity Index (MASI) score in Group-A was 53.88±18.36% and in Group-B 39.66±14.53%. The mean reduction in MASI score was significantly higher in Group-A when compared to Group-B. Conclusion: Topical 4% hydroquinone cream is more effective but had more side effects as compared to combination of 10% glutathione plus 5% ascorbic acid cream for epidermal melasma in Asian skin types.

目的:本研究旨在比較局部4%對苯二酚乳膏與局部10%穀胱甘加5%抗壞血酸乳膏對表皮黃褐斑患者的療效和安全性。方法:這是一項隨機對照試驗,其中根據納入標準招募了70名患者,並將其隨機分為兩組,每組各35名患者。A組患者每天晚上局部給予4%對苯二酚乳膏,B組患者每天同樣時間局部給予10%穀胱甘加5%抗壞血酸乳膏聯合用藥。連續治療十六週,並在最後一次治療的八週後覆診,合計二十四周後評估療效。每次訪問均有監測副作用。結果:A組的黃褐斑面積和嚴重程度指數得分平均降低了53.88±18.36%,B組該指數則平均降低了39.66±14.53%。A組的黃褐斑面積和嚴重程度指數得分平均降低幅度明顯較B組為高。結論:與10%穀胱甘加5%抗壞血酸乳膏聯合治療相比,局部4%對苯二酚乳膏對亞洲皮膚人士的表皮黃褐斑相更為有效,但副作用亦更多。

Keywords: Epidermal Melasma, Glutathione, Hydroquinone

關鍵詞: 表皮黃褐斑、穀胱甘肽、對苯二酚