Table of Content


Autumn 2019, Vol. 27 No. 3

Hong Kong J. Dermatol. Venereol. (2019) 27, 131-135

Case Report

Paraneoplastic myasthenia gravis associated with Merkel cell carcinoma


DL Lankenau Vela, H Decanini Arcaute, F De la Garza Salazar


Background: Merkel cell carcinoma (MCC) is an unusual primary neuroendocrine cutaneous carcinoma which may rarely may be associated with neurological paraneoplastic syndromes. Nevertheless, the coexistence of myasthenia gravis (MG) with MCC has not been previously reported. History: A 74-year-old man presented with dysphagia, tetraparesis, horizontal diplopia and right palpebral ptosis. MG was diagnosed and treatment with piridostigmine and IV immunoglobulin was given, leading to a partial response. Two weeks later, there was rapid growth of a painless left suprapatellar nodule which was compatible with MCC. Conclusion: Merkel cell carcinoma may rarely present as refractory MG. Tumour excision may be necessary for resolution of the syndrome.


Keywords: Merkel cell carcinoma, myasthenia gravis, paraneoplastic neurological syndrome

關鍵詞: 麥克氏細胞癌、重症肌無力、腫瘤附屬神經綜合徵