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Autumn 2019, Vol. 27 No. 3

Hong Kong J. Dermatol. Venereol. (2019) 27, 107-119


Original Article

Lymphomatoid papulosis: a case series in Hong Kong

淋巴瘤樣丘疹病:香港的病例系列之一

HF Cheng 鄭學輝, SC Ng 吳順展, MMT Ng 吳孟婷

Abstract

Background: Lymphomatoid papulosis is considered a clinically benign disease with an alarming cytomorphology. Its association with lymphoma is well recognised. This study serves to review the latest local data and provide a better understanding. Objective: We report a case series of lymphomatoid papulosis in Hong Kong, focusing on its clinical and histopathological features. The association with second lymphoma was also studied. Methodology: The biopsy histopathology and immunohistochemical findings, together with clinical records of patients diagnosed with lymphomatoid papulosis were retrieved from 2010 to 2018. The findings were then reviewed and compared with the published data. Results: Ten patients and 14 biopsy-confirmed cases of lymphomatoid papulosis were identified. The majority were of type A and CD30 positivity was noted in all cases. Although the disease ran a relapsing course, there were no mortalities. Only one patient developed mycosis fungoides. Conclusion: Findings of this local series are in line with published data. Clinicopathological correlation is important in managing patients with lymphomatoid papulosis. Life-long follow-up is recommended due to its chronic recurrent course and risk of development of lymphoma.

背景:淋巴瘤樣丘疹病被認為是臨床上良性的疾病,但有著令人擔憂的細胞形態學表現。它與淋巴瘤的相關聯是無可置疑的。本研究旨在回顧最新的本地數據以提供更好的理解。目的:我們報告了一系列香港的淋巴瘤樣丘疹病個案,重點是其臨床和組織病理學特徵。還研究了與繼後的淋巴瘤的相關聯。方法:我們檢索了2010年到2018年的活檢組織病理學和免疫組化結果,以及淋巴瘤樣丘疹病患者的臨床記錄。然後對以上結果進行了回顧,並與公佈的數據進行了比較。結果:確定了10名患者的14例活檢確診的淋巴瘤樣丘疹病病例。大多數是A型,並且所有病例都是分化簇30陽性。雖然病情反覆,但沒有死亡個案。只有一名患者患上了蕈狀肉芽腫。結論:此本地系列結果與已公佈數據一致。臨床病理學相關性對於治療淋巴瘤樣丘疹病患者實為重要。因此病的慢性復發病情和淋巴癌的潛在發生風險,故建議終身覆診跟進。

Keywords: CD30, histopathology, immunohistochemistry, lymphomatoid, papulosis

關鍵詞: 分化簇30、組織病理學、免疫組織化學染色法、淋巴瘤樣、丘疹病