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Autumn 2018, Vol. 26 No. 3

Hong Kong J. Dermatol. Venereol. (2018) 26, 103-112


Original Article

Meta-analysis of the efficacy of 5-aminolevulinic acid photodynamic therapy for the treatment of flat warts

統合分析5 - 氨基乙酰丙酸光動力療法治療扁平疣的療效

Y Ding, X Li, R Wei, H Fang

Abstract

Objective: We systematically evaluated the efficacy and safety of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) for treating flat warts. Methods: Studies in the Wanfang Database, VIP journals, CNKI, PubMed, and EBSCO databases published between January 1990 and September 2015 were retrieved according to the inclusion and exclusion criteria. The studies were screened and evaluated for quality; Review Manager 5.2 software was used to perform meta-analysis of the included studies. Results: A total of nine randomised controlled trials comprising 823 patients were enrolled. The meta-analysis results showed that ALA-PDT exhibited better efficacy than CO2 laser and liquid nitrogen cryotherapy in reducing the relapse rate and adverse reactions and demonstrated a better cure rate than imiquimod cream. Conclusion: As ALA-PDT has a low relapse rate and clinical adverse reactions and is effective for the treatment of flat warts.

目的:我們有系統地評估了5-氨基乙酰丙酸光動力療法治療扁平疣的療效和安全性。方法:根據納入和排除標準檢索1990年1月至2015年9月期間發表的萬方數據庫、維普網期刊、中國國知網、PubMed和EBSCO數據庫。對這些研究進行篩選並評估其質量;並用Review Manager 5.2軟件對納入的研究進行統合分析。結果:共納入九個隨機對照試驗,當中包括823名患者。統合分析結果顯示,5-氨基乙酰丙酸光動力療法在降低復發率和不良反應方面表現出比二氧化碳激光和液氮冷凍療法的療效更好,並且比咪喹莫特乳膏有著更好的治愈率。結論:5-氨基乙酰丙酸光動力療法的複發率和臨床不良反應較低,對治療扁平疣實為有效。

Keywords: 5-aminolevulinic acid photodynamic therapy, Flat warts, Meta-analysis

關鍵詞: 5-氨基酮戊酸光動力治療、扁平疣、Meta分析