Table of Content


Spring 2018, Vol. 26 No. 1

Hong Kong J. Dermatol. Venereol. (2018) 26, 10-17

Review Article

Human demodicidosis and the current treatment options


NS Lam 林兆麒, X Long 龍鑫鑫, RC Griffin, JCG Doery, F Lu 呂芳麗


Demodex folliculorum and D. brevis live and reproduce in the pilosebaceous unit, including hair follicles and sebaceous glands. Various treatments have been found to be effective in managing Demodex-related diseases. The possible effects of the treatments are to decrease the mite counts, relieve the related symptoms, and to modulate the immune system. Metronidazole, ivermectin, and permethrin are effective drugs for treating Demodex infections. A combination of different treatments is needed occasionally for refractory cases, especially those with genetic susceptibility or immuno-compromised conditions. Although the current treatments are effective in controlling Demodex mite population and the related symptoms, more investigations are needed to enhance efficacy by improved drug delivery technologies and alternative treatments with less toxicity, a lower risk of resistance, and better side-effects profile. This review summarises the current oral and topical treatments on human demodicidosis, their possible mechanisms of action, and side effects.


Keywords: Crotamiton, demodicidosis, ivermectin, lindane, metronidazole, permethrin

關鍵詞: 丁烯醯苯胺、蠕形蟎病、伊維菌素、林丹、甲硝唑、氯菊酯