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Winter 2017, Vol. 25 No. 4

Hong Kong J. Dermatol. Venereol. (2017) 25, 187-191


Case Report

A case of primary cutaneous Langerhans cell sarcoma clinically mimicking pyogenic granuloma

臨床形似化膿性肉芽腫的原發性皮膚朗格漢斯細胞肉瘤一例

O Kwon 權五勝, KD Park 朴璟德, H Chung 鄭炫, JB Park 朴栽福, JY Park 朴志英, DH Shin 申東薰, J Park 朴埈秀

Abstract

Langerhans cell sarcoma (LCS) is a rare neoplasm of Langerhans cell lineage with prominent malignant cytological features. Currently, complex histological evaluation is required for accurate diagnosis and treatments providing have not been standardised due to its rarity. A thirty-five-year-old female patient presented with a solitary coin-sized dome-shaped mass on the left shin for two months. Histology confirmed Langerhans cell sarcoma with immunohistochemical stains being positive for S-100, Ki-67 and CD1a. Herein, we present a rare case of a single-site LCS in light of expanding the currently available knowledge on LCS and to underline the importance of immunohistochemical analysis since Langerhans cell sarcoma may cause diagnostic confusion due to clinical and histological similarities with other diseases.

朗格漢斯細胞肉瘤是一種罕見的朗格漢斯細胞系腫瘤,具有顯著的惡性細胞學特徵。礙於其罕有而尚未有標準化,目前需進行複雜的組織學評估才能確診此病。一名三十五歲的女病人在其左小腿前端出現了一個單一像硬幣般大小的圓拱形腫塊,歷時兩個月之久。綜合S-100、Ki-67和CD1a的免疫組織化學染色皆呈陽性,組織學證實為朗格漢斯細胞肉瘤。我們在這裡提出了一例罕見的單一位置朗格漢斯細胞肉瘤,希望能增長此病現有的認知,並強調免疫組織化學分析的重要性,來避免因朗格漢斯細胞肉瘤與其他疾病在臨床和組織學上的相似性,做成診斷上的混淆。

Keywords: Langerhans cell sarcoma, malignant melanoma, pyogenic granuloma

關鍵詞: 朗格漢斯細胞肉瘤、惡性黑色素瘤、化膿性肉芽腫