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Summer 2017, Vol. 25 No. 2

Hong Kong J. Dermatol. Venereol. (2017) 25, 84-89


Case Report

Necrobiotic xanthogranuloma: a report of two fascinating cases

漸進性壞死性黃色肉芽腫:兩宗趣味盎然的病例報告

R Minocha, S Lee 李啟焱, JYJ Choi 崔榮埈, S Mann

Abstract

Necrobiotic xanthogranuloma (NXG) is a rare granulomatous disorder of the skin. It is characterised by indurated nodules and erythematous, yellow plaques mostly affecting the periorbital region. In recent years, NXG has been increasingly associated with paraproteineamia and haematological disorders, such as multiple myeloma. Hereunder we report two cases with histological and clinical findings of NXG. We believe that case one is the first report case of NXG on a background of hepatitis C and case two is the first case report of extrafacial unilateral NXG to our knowledge.

漸進性壞死性黃色肉芽腫是一種罕見的肉芽腫類皮膚病。其特徵在於硬化結節和紅黃色斑塊,大多影響眼眶週圍。近年來,此病已經越來越多地發現與副蛋白血症和其他血液學疾病如多發性骨髓癌相關。下文我們報告了兩例漸進性壞死性黃色肉芽腫的組織學和臨床表現。我們相信案例一是此病有著丙型肝炎背景的首宗病例報告;案例二,則是我們所知道此病顏面外單側發病的首宗病例報告。

Keywords: Disfigurement, hepatitis C, Necrobiotic xanthogranuloma, systemic involvement, unilateral

關鍵詞: 毀容、丙型肝炎、漸進性壞死性黃色肉芽腫、全身性累及、單側