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Summer 2017, Vol. 25 No. 2

Hong Kong J. Dermatol. Venereol. (2017) 25, 57-64


Original Article

Comparative study of quality of life between psoriasis, vitiligo and autoimmune bullous disease

銀屑病、白癜風和自身免疫性大皰性疾病之間的生活質量比較研究

ST Xu 許舒婷, EH Oh 吳義賢, JE Kim 金廷恩, JY Ko 高周延, YS Ro 魯英錫

Abstract

Background: Psoriasis, vitiligo and autoimmune bullous disease are chronic relapsing dermatological diseases that affect patients' daily life and psychosocial well-being. Although the impact of these diseases on quality of life (QoL) has been reported respectively, the comparison of the QoL between psoriasis, vitiligo and autoimmune bullous disease patients has not been investigated in Korea. Objective: The purpose of this study was to compare the QoL between psoriasis, vitiligo and autoimmune bullous disease by using Dermatology Life Quality Index (DLQI), Medical Outcome Study Short Form 36 (SF-36) and Skindex-29 questionnaires. Methods: From June 2014 to August 2016, 150 patients were selected from outpatient clinic of Department of Dermatology of Hanyang University Seoul Hospital. Results: A total of 364 questionnaires were valid, of which 150 cases with the male to female ratio is 1:1.08. By comparing the scores of Skindex-29 between three groups, we found that autoimmune bullous disease was associated with lower QoL than psoriasis and vitiligo (p<0.001). The total score of DLQI was higher in psoriasis group (8.06) than in vitiligo group (4.49) and the scores of SF-36 items showed similar result, which detected a worse QoL in patients with psoriasis than in vitiligo. Significant correlations were found between DLQI, SF-36 and Skindex-29 scores in all disease groups (p<0.01). Conclusion: The results show that there is significant impairment of QoL in these three skin diseases. The high correlation between the instruments used in this study implies that any one of them might be useful to measure QoL.

背景:銀屑病,白癜風和自體免疫性大皰性疾病是慢性的,反復發作性的皮膚病,嚴重影響了患者的日常生活和心理健康。儘管有一些研究致力於評價這些疾病對生活質量的影響,但在韓國還沒有將三個疾病造成的影響進行對比的研究出現。目標:利用Dermatology Life Quality Index (DLQI), Medical Outcome Study Short Form 36 (SF-36)和Skindex-29三種生活質量量表來對比銀屑病,白癜風和自體免疫性大皰性疾病分別對患者生活質量的影響。方法:2014年6月至2016年8月,共150名韓國漢陽大學首爾醫院的皮膚科門診患者完成了問卷調查。結果:共有364份問卷被完成,150名患者的男女比例是1:1.08。通過三組疾病的Skindex-29問卷結果,我們發現自體免疫性大皰性疾病對患者生活質量的影響較其他兩組大(p<0.001)。銀屑病組的DLQI平均分數為8.06,比白癜風組的4.49高,而SF-36的平均分數也展示了相同結果,體現銀屑病患者的生活質量比白癜風低。在所有組的結果中,DLQI, SF-36和Skindex-29三個量表結果之間都展示了顯著性相關(p<0.01)。結論:結果表明,三種疾病的患者的生活質量都嚴重受到了影響。三種量表結果之間的高度相關意味著也許可以使用其中任意一種來測量三種疾病的生活質量。

Keywords: Autoimmune bullous disease, Korea, Psoriasis, Quality of Life, Vitiligo

關鍵詞: 自體免疫性大皰性疾病、韓國、銀屑病、生活質量、白癜風