Table of Content


Winter 2016, Vol. 24 No. 4

Hong Kong J. Dermatol. Venereol. (2016) 24, 201-204

Case Report

Nicolau syndrome: a rare complication of injection that should be kept in mind


SP Kartal, M Alper, N Gürçay


Nicolau syndrome (NS) is a rare cutaneous necrosis occurring at the site of injection. It presents with instant and severe pain around the injection site followed by necrosis. Several drugs have been reported to cause NS. Here, a case of NS who healed with a large scar due to the intramuscular injection of a novel mixture of thiocolchicoside and diclofenac sodium is presented. In cases of NS, the physical and chemical properties of drugs, injection speed, and the route of administration should be considered.


Keywords: Cutaneous necrosis, injection complication, Nicolau syndrome

關鍵詞: 皮膚壞死、注射併發症、尼古拉斯綜合徵