Table of Content


Winter 2016, Vol. 24 No. 4

Hong Kong J. Dermatol. Venereol. (2016) 24, 184-190

Review Article

A case series and clinical update on calciphylaxis


A Grant and S Lee 李啟焱


Department of Dermatology, Concord Repatriation General Hospital, Hospital Road, Concord, NSW 2139, Australia Calciphylaxis is a rare disorder characterised by microvascular calcification and thrombosis often leading to rapidly progressing ulceration and tissue necrosis. It most commonly affects patients with chronic renal disease. Clinical findings are variable although painful lower limb lesions are characteristic. Some cases can be diagnosed on clinical grounds. However there are useful diagnostic adjuncts. Differential diagnosis includes atherosclerotic vascular disease, pyoderma gangrenosum, vasculitis, necrobiosis lipoidica and warfarin necrosis. Sadly, treatment remains largely supportive. There is a need for heightened interest and targeted research.


Keywords: Amputation, calciphylaxis, diabetes, mortality, renal failure

關鍵詞: 截肢、鈣化防禦症、糖尿病、死亡率、腎衰竭