Table of Content

Archive

Autumn 2016, Vol. 24 No. 3

Hong Kong J. Dermatol. Venereol. (2016) 24, 120-128


Review Article

Effectiveness of external topical medications in the treatment of keloid scars: a review

文獻回顧:外部外用藥物在瘢痕瘤的治療成效

S Wang 王珍 and J Yap 葉俊良

Abstract

Department of Family Medicine, SingHealth Polyclinics-Marine Parade, Blk 80 Marine Parade Central, #01-792 Singapore 440080 Keloid scars may cause itch, pain and psychological distress. Topical medications are easily administered, painless, and accessible. This article reviews their effectiveness. The primary and secondary outcomes were scar size and symptom reduction respectively. Ten randomised controlled trials were included, involving 317 subjects. Four papers showed topical silicone reduced keloid size, two reported no improvement. Addition of vitamin E was superior to silicone gel sheeting alone in reducing scar symptoms. Onion extract and hydration and occlusion showed a reduction in scar size and symptoms. Most evidence supports the use of silicone. Further trials are needed to evaluate alternative external medications.

瘢痕瘤疤痕可以構成瘙癢、疼痛和心理困擾。外用藥物不單使用方便和無痛,且容易獲取。本文回顧了瘢痕瘤外部外用藥物的功效。首要和第二成果分別被設定為疤痕的大小和症狀減少。我們篩選了十個隨機對照試驗,共涉及317名患者。當中有四個研究顯示外用矽膠減少了瘢痕瘤的大小,反之兩個報告沒有改善。而添加了維生素E的矽凝膠膜對改善疤痕症狀的效果,優勝於單獨使用。洋蔥提取物和水潤及密封亦顯示出能減少疤痕的大小和症狀。總括來說,大多數證據都支持矽膠的使用,而其他的替代外部藥物,側需進一步研究評估。

Keywords: External, keloid, scar, topical, treatment

關鍵詞: 外部、瘢痕瘤、疤痕、外用、治療