Table of Content


Autumn 2016, Vol. 24 No. 3

Hong Kong J. Dermatol. Venereol. (2016) 24, 120-128

Review Article

Effectiveness of external topical medications in the treatment of keloid scars: a review


S Wang 王珍 and J Yap 葉俊良


Department of Family Medicine, SingHealth Polyclinics-Marine Parade, Blk 80 Marine Parade Central, #01-792 Singapore 440080 Keloid scars may cause itch, pain and psychological distress. Topical medications are easily administered, painless, and accessible. This article reviews their effectiveness. The primary and secondary outcomes were scar size and symptom reduction respectively. Ten randomised controlled trials were included, involving 317 subjects. Four papers showed topical silicone reduced keloid size, two reported no improvement. Addition of vitamin E was superior to silicone gel sheeting alone in reducing scar symptoms. Onion extract and hydration and occlusion showed a reduction in scar size and symptoms. Most evidence supports the use of silicone. Further trials are needed to evaluate alternative external medications.


Keywords: External, keloid, scar, topical, treatment

關鍵詞: 外部、瘢痕瘤、疤痕、外用、治療