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Summer 2016, Vol. 24 No. 2

Hong Kong J. Dermatol. Venereol. (2016) 24, 65-69


Original Article

Pigmented purpuric dermatosis in Singapore: a clinic-epidemiological characterisation

新加坡的色素性紫癜性皮膚病之臨床及流行病學特徵

MQM Liau 廖美琪, V Long 龍詩歡, SS Yang 楊時耀, KB Tan 陳光明, DCW Aw 胡政偉

Abstract

Background: Pigmented purpuric dermatoses (PPD) are a group of chronic and relapsing disorders characterised by petechiae and pigmented macules. To date, very few studies have evaluated the clinico-epidemiology of this disorder. Aim: To describe the local epidemiology of patients with PPD in a tertiary dermatological unit in the National University Hospital, Singapore over a 5-year period. Methods: A retrospective analysis of all biopsy-confirmed PPD cases diagnosed and treated in NUH in the period 2009-2014, was performed. Patient demographics, clinical characteristics, comorbidities and treatment outcomes were noted. Results: A total of 48 patients were identified. PPD tends to affect older adults and has a slight female preponderance in our population. The lower limbs were the most common site of involvement. There were no significant comorbidities identified in association with our patients with PPD. The rates of improvement were similar for treatment and non-treatment groups. Limitations: Retrospective review, small sample size, selection bias from inclusion of only biopsy-proven cases. Conclusion: Most patients were asymptomatic and those who experience symptoms may benefit from topical corticosteroid therapy. As spontaneous improvement is often observed, treatment is not always necessary.

背景:色素性紫癜性皮膚病是一組特點為點狀色素沉著的慢性和復發性皮膚疾病。迄今為止,很少研究評估此病的臨床及流行病學。目的:回顧新加坡國立大學醫院內的一所三級皮膚病單位五年內所診治的色素性紫癜性皮膚病患者,來描述此病的當地流行病學。方法:對二零零九年至二零一四年間在國立大學醫院診治的所有活檢證實的色素性紫癜性皮膚病個案進行了回顧性分析,並一一紀錄病人的人口統計資料、臨床特徵、合併症和治療結果。結果:本研究共篩選出四十八名色素性紫癜性皮膚病患者,發病多見於老年,而女性較男性稍多;下肢為最常的發病部位。在我們的患者當中,沒有發現顯著的相關聯合併症,而治療組和非治療組的改善率結果分別不大。限制:回顧性調查、樣本數較小、僅列入活檢證實個案所存在的選擇偏差。結論:多數患者毫無症狀,其餘受症狀困擾的患者在外用皮質類固醇治療後情況多有改善。由於察覺到不少患者可不藥而癒,固非所有患者都要施以藥物治療。

Keywords: Corticosteroids, pigmented purpuric dermatosis (PPD), topical corticosteroids

關鍵詞: 皮質類固醇、色素性紫癜性皮膚病、外用皮質類固醇