Table of Content

Archive

Spring 2016, Vol. 24 No. 1

Hong Kong J. Dermatol. Venereol. (2016) 24, 17-23


Review Article

Microbes and atopic dermatitis: The Yin and Yang of barrier and immune dysfunction

微生物與異位性皮膚炎：皮膚屏障和免疫功能障礙的陰陽律

BE Cohen and SJ Orlow

Abstract

Atopic dermatitis (AD) is a chronic, inflammatory skin condition caused by a complex interaction of genetic and environment factors. Inherited defects within the stratum corneum are increasingly recognised as a key causative factor in the development of AD. Patients with AD also demonstrate a high rate of colonisation by microbes, notably Staphylococcus aureus. Controversy exists regarding the use of antimicrobial agents in the management of AD. We briefly review the role of stratum corneum dysfunction in AD, the influence of cutaneous colonisation and infections, and provide an update on the utility of anti-staphylococcal treatment in AD.

異位性皮膚炎是由遺傳和環境因素兩者複雜相互作用而引致的一種慢性皮膚炎症。皮膚角質層內的遺傳缺陷被逐漸認定為此病的重要致病因素；同時，患者身上的微生物定植量亦偏高，特別是金黃色葡萄球菌。因此，在異位性皮膚炎的治理中應否使用抗菌劑亦一直存在爭議。在本文中，我們會簡要回顧角質層功能障礙在異位性皮膚炎中所扮演的角色和皮膚定植及感染累及的影響，並提供最新的抗葡萄球菌治療在異位性皮膚炎中的應用資訊。

Keywords: Anti-bacterial agents, atopic dermatitis, epidermis, Staphylococcus

關鍵詞: 抗菌劑、異位性皮膚炎、表皮、葡萄球菌