Table of Content


Spring 2016, Vol. 24 No. 1

Hong Kong J. Dermatol. Venereol. (2016) 24, 17-23

Review Article

Microbes and atopic dermatitis: The Yin and Yang of barrier and immune dysfunction


BE Cohen and SJ Orlow


Atopic dermatitis (AD) is a chronic, inflammatory skin condition caused by a complex interaction of genetic and environment factors. Inherited defects within the stratum corneum are increasingly recognised as a key causative factor in the development of AD. Patients with AD also demonstrate a high rate of colonisation by microbes, notably Staphylococcus aureus. Controversy exists regarding the use of antimicrobial agents in the management of AD. We briefly review the role of stratum corneum dysfunction in AD, the influence of cutaneous colonisation and infections, and provide an update on the utility of anti-staphylococcal treatment in AD.


Keywords: Anti-bacterial agents, atopic dermatitis, epidermis, Staphylococcus

關鍵詞: 抗菌劑、異位性皮膚炎、表皮、葡萄球菌