Table of Content


Autumn 2015, Vol. 23 No. 3

Hong Kong J. Dermatol. Venereol. (2015) 23, 121-125

Case Report

Topical sulphamethoxazole ophthalmic solution induced toxic epidermal necrolysis


LC Wu 吳隆基 and CC Chen 陳志強


Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction that leads to widespread mucocutaneous necrosis. Medications are the most common cause of TEN. However, some cases develop following infection or vaccination. TEN is very rarely induced by topical ophthalmic solution or topical agent. We report a case of a 31-year-old female who developed TEN after using topical sulphamethoxazole ophthalmic solution. Skin biopsy was performed and revealed upper epidermal necrosis with cell-poor inflammatory infiltrate. After admission, the patient received systemic and topical corticosteroid, as well as supportive treatment. The prognosis was good at follow-up 21 days later.


Keywords: Erythema multiforme, ocular solutions, Stevens-Johnson syndrome, sulphamethoxazole, toxic epidermal necrolysis

關鍵詞: 多形性紅斑、眼部溶液、史蒂芬強森症候群、磺胺甲噁唑、中毒性表皮壞死鬆解症