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Spring 2015, Vol. 23 No. 1

Hong Kong J. Dermatol. Venereol. (2015) 23, 5-12


Original Article

A study of point-of-care test to diagnose syphilis in Hong Kong

定點照護測試於香港診斷梅毒的研究

CC Koh許招財, CK Ho何正綱, KM Ho何景文

Abstract

Background: In Hong Kong, a 'point-of-care' test (POC) syphilis test is used by some outreach teams of non-government organisations (NGO) for screening syphilis. In Hong Kong, in the public sector, sexually transmitted infections are seen at the outpatient clinics under the Social Hygiene Service. Objective: This study aimed to determine the performance of POC syphilis test among high risk people in Hong Kong. Methods: Patients were recruited from two Social Hygiene Clinics for the POC syphilis test. From October 2012 to February 2013, the following groups were recruited: (1) new attendees; (2) patients with newly diagnosed syphilis; (3) patients with a history of treated syphilis. Two different POC syphilis tests [Alere DetermineTM Syphilis TP ("Alere Ltd", USA), Standard Diagnostics Bioline Syphilis 3.0 (Standard Diagnostics, Inc., Korea)] were performed. Results: A total of 356 patients were recruited. Overall results for Alere DetermineTM Syphilis TP ("Alere Ltd", USA) test was as follows: sensitivity 56.1%, specificity 100%. Overall results for Standard Diagnostics Bioline Syphilis 3.0 (Standard Diagnostics, Inc., Korea) test was as follows: sensitivity 57.4%, specificity 100%. Conclusion: Alere DetermineTM Syphilis TP ("Alere Ltd", USA) and Standard Diagnostics Bioline Syphilis 3.0 (Standard Diagnostics, Inc., Korea) tests have high specificity in this study but high sensitivity in previous studies cannot be reproduced. Validation of POC syphilis test may be required before its use as a standard screening test for syphilis.

背景:在香港,有一些非政府組織外展團隊會使用梅毒定點照護測試來篩查梅毒,而在公營醫療系統,性病診療多在社會衞生科診所內進行。目標:這項研究的目的是要測試梅毒定點照護測試在香港高風險人群中的準確性。方法:病人是從兩個社會衞生科診所選出,從2012年10月到 2013年2月,我們招募新到診病人、新患梅毒病人、舊有已確診梅毒病人,進行兩種不同定點梅毒照護測試[Alere DetermineTM Syphilis TP ("Alere Ltd", USA) 及Standard Diagnostics Bioline Syphilis 3.0 (Standard Diagnostics, Inc., Korea)]。結果:此研究招募了356個病人,Alere DetermineTM Syphilis TP ("Alere Ltd", USA) 梅毒定點照護測試結果如下:靈敏度56.1%,特異度100%。Standard Diagnostics Bioline Syphilis 3.0 (Standard Diagnostics, Inc., Korea) 梅毒定點照護測試結果如下:靈敏度57.4%,特異度100%。結論:在這項研究中,Alere DetermineTM Syphilis TP ("Alere Ltd", USA)和 Standard Diagnostics Bioline Syphilis 3.0 (Standard Diagnostics, Inc., Korea) 梅毒定點照護測試特異度高但靈敏度低於以往的研究。作為標準的篩選梅毒測試前,梅毒定點照護測試的有效性值得再作研究。

Keywords: Syphilis, point-of-care syphilis test, Social Hygiene Clinic, Hong Kong

關鍵詞: 梅毒、梅毒定點照護測試、社會衞生科、香港