Table of Content

Archive

Winter 2013, Vol. 21 No. 4

Hong Kong J. Dermatol. Venereol. (2013) 21, 191-195


Case Report

Using intralesional corticosteroids to treat significant periorbital oedema due to imatinib

以病灶內注射皮質類固醇治療伊馬替尼引致的嚴重眼眶周圍水腫一例

YC Kho and S Lee 李啟焱

Abstract

We report the first case of intralesional corticosteroids being successfully used to treat significant periorbital oedema secondary to imatinib therapy. The patient's quality of life was significantly impaired as a result of her ongoing imatinib treatment for an underlying malignancy. While this approach mitigates the risks associated with surgery, in rare cases it can result in retinochoroidal vascular occlusion from crystalline corticosteroid aggregates. Accordingly, periorbital corticosteroid injections should only be considered as a treatment option in carefully selected patients. Fortunately, our patient has thus far enjoyed a favourable outcome, with minimal periorbital oedema observed two years after dermatological intervention.

我們報告首宗病灶內注射皮質類固醇成功治療伊馬替尼引致的嚴重眼眶周圍水腫個案。個案中,病人因為患有癌症,需要持續使用伊馬替尼治療,生活質素深受藥物副作用影響。雖然注射方法相對手術來說風險較少;但在極少的個案中,它可能會因皮質類固醇的結晶集合體而導致視網膜脈絡膜血管閉塞。因此,在考慮眼眶周圍皮質類固醇注射治療方案時,必須小心篩選合適患者。幸運地,在皮膚科治療計起兩年後,我們的病人迄今仍保持良好療效,只有些微的眼眶周圍水腫。

Keywords: Gastrointestinal stromal tumours, imatinib, periorbital oedema, intralesional steroid injections, quality of life improvement

關鍵詞: 胃腸道基質瘤、伊馬替尼、眼眶周圍水腫、病灶內注射類固醇、生活質素改善