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Summer 2013, Vol. 21 No. 2

Hong Kong J. Dermatol. Venereol. (2013) 21, 73-77


Case Report

Pemphigus foliaceus complicated by disseminated cutaneous herpes simplex virus infection in an elderly man

一名患有落葉性天皰瘡與及廣泛性單純皰疹病毒皮膚感染的長者個案

HF Cheng 鄭學輝, MS Lam 林木森, KH Tsang 曾冠豪, WC Ho 何穎莊, WF Ng 吳維富, WK Kwan 關煒強

Abstract

Pemphigus foliaceus is an immunobullous disease which commonly presents with erosions, ulcerations and crusting. In immunocompromised hosts, disseminated cutaneous herpes simplex infection may also present in a similar fashion. It may be difficult to distinguish between them on clinical grounds alone and their co-existence poses both a diagnostic and therapeutic challenge. We report a case of pemphigus foliaceus complicated by disseminated cutaneous herpes simplex infection. Systemic acyclovir plus systemic steroids hastened the clinical recovery within a month. The clinical features will be discussed together with a literature review.

落葉型天疱瘡是一種免疫大皰病,通常表現為皮膚糜爛、潰瘍和結痂。在免疫功能低下的病人,播散性單純疱疹病毒感染發生在皮膚時,也可出現類似病徵。臨床上要區分兩者存在一定困難,若果兩者同時發生,更是診斷和治療上的一大挑戰。我們報告一例落葉型天疱瘡併發廣泛性皮膚單純疱疹病毒感染,在同時接受全身性阿昔洛韋及類固醇治療後,一個月內得以快速痊癒。此病的臨床特徵及其文獻回顧將會在此文中一併討論。

Keywords: Disseminated herpes simplex virus infection, pemphigus foliaceus

關鍵詞: 播散性皮膚單純疱疹病毒感染、落葉型天疱瘡