Table of Content


Winter 2012, Vol. 20 No. 4

Hong Kong J. Dermatol. Venereol. (2012) 20, 153-161

Original Article

Cutaneous sarcoidosis: a case series from a regional hospital in Hong Kong


MM Chang 張苗, PCL Choi 蔡祥龍, FFC Ip 葉方正


Sarcoidosis is a non-caseating granulomatous systemic disorder of unknown aetiology. It is seldom reported in Asians and local data is lacking. We report a retrospective cohort of patients with cutaneous sarcoidosis in a tertiary referral hospital from January 2002 to December 2011. We aim to describe the epidemiological pattern and cutaneous involvement in a predominantly-Chinese population. Sarcoidosis was diagnosed in 10 patients and all had pulmonary involvement. Cutaneous sarcoidosis was diagnosed in five patients: four were Chinese, one was Caucasian. Cutaneous manifestations included plaques, nodules and non-scarring alopecia. There was a case with acute presentation as Löfgren's syndrome. Other extra-cutaneous involvement included eye, muscle and joint. Histopathological examination revealed non-caseating epithelioid granulomas with variable infiltrates in the dermis without the presence of infection or foreign body. The mainstay of treatment was topical or systemic corticosteroids to which most patients had a good response. No mortality was noted. In general, cutaneous sarcoidosis is rare in Chinese and a thorough evaluation for systemic involvement is necessary.

類肉瘤病是一種非乾酪性肉芽腫,其病因不明的全身性疾病。這是很少在亞洲人中報導,亦缺乏本地數據。我們報告一個從二零零二年一月至二零一一年十二月在一間第三轉診推薦醫院類肉瘤 病患者的回顧性隊列研究。我們的目標是描述這病在一個以中國人為主要人口的流行病學模式和皮膚的牽連。十個患者被診斷為類肉瘤病。他們所有都有肺部牽連。五例被確診為皮膚類肉瘤病: 四個是中國人,一個是高加索人。皮膚表現包括斑塊、結節和無疤痕的脫髮。有一宗個案為洛夫格倫綜合症的急性表現。其他皮膚以外的牽連,包括眼睛,肌肉和關節。病理組織學檢查發現在 真皮層內有非乾酪性上皮樣肉芽腫及可變的滲入,而沒有感染或異物。主要的治療方法是外用或內服皮質類固醇,大部份患者都有良好的反應。並無死亡個案。在一般情況下,皮膚類肉瘤病在 中國人中是罕見的,深入的系統性評估是必要的。

Keywords: Cutaneous sarcoidosis, non-caseating granuloma, sarcoidal granuloma, sarcoidosis

關鍵詞: 皮膚類肉瘤病,非乾酪性肉芽腫,類肉瘤肉芽腫,類肉瘤病