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Summer 2012, Vol. 20 No. 2

Hong Kong J. Dermatol. Venereol. (2012) 20, 53-59


Original Article

A study of topical methyl-aminolevulinate red-light photodynamic therapy in the treatment of squamous cell carcinoma-in-situ in Chinese patients: a Singaporean experience

新加坡的光動力療法經驗:一項對鱗狀上皮細胞原位癌的華裔患者使用外用甲基氨基乙酰丙酸紅光光動力療法的研究

CSL Koh 高淑玲, HY Chia 謝慧儀, C Theng 唐添成, WS Chong 張維盛

Abstract
Topical photodynamic therapy is used in the treatment of Bowen's disease (BD). This is a retrospective review of the data of Chinese patients with BD who have undergone photodynamic therapy at the National Skin Centre from March 2006 to March 2010. A total of 43 Chinese patients with 56 histologically confirmed BD were included. The clearance rate at 3 months was 73.2%. Pain was the most common side effect. The clearance rate in our patients is lower than rates cited in current literature. Future prospective studies utilizing topical PDT in the treatment of BD in Asian skin are needed to evaluate its efficacy in Asian patients.

外敷光動力療法是鮑恩氏病的其中一種治療方法。本研究回顧分析了新加坡國家皮膚病中心,自二零零六年三月至二零一零年三月間,對華裔鮑恩氏病患者所施行的光動力治療。當中包括四十 三名華裔病患,計有五十六個組織學確立的鮑恩氏病病灶。三個月的清除率為百分之七十三點二;疼痛是最常見的副作用。我們病患的清除率相對當前文獻記載為低,故需要進一步的前瞻性研究 去釐清外敷光動力療法對亞洲人膚色的鮑恩氏病之成效。

Keywords: Asian, Bowen's disease, Fitzpatrick skin phototype IV, Photodynamic therapy

關鍵詞: 亞洲人,鮑恩氏病,第五型曝光反應的膚質類型,光動力療法