Archive

Spring 2012, Vol. 20 No. 1

Hong Kong J. Dermatol. Venereol. (2012) 20, 5-11

Original Article

Reticulohistiocytosis: a case series in Hong Kong

網狀組織細胞增多症：香港的個案系列

CC Koh 許招財 and KK Jong 莊國坤

Abstract
Background: Reticulohistiocytosis is a rare histiocytic proliferative disorder one form of which, multicentric reticulohistiocytosis, may mimic rheumatoid arthritis. Objective: To report on a case series of reticulohistiocytosis in Hong Kong and focus on the clinical presentation and course of disease. Materials and method: Case records with the biopsy results of reticulohistiocytoma in the period of 2005 to 2011 were retrieved from the database of the Social Hygiene Service, Department of Health, Hong Kong. Results: Three cases of reticulohistiocytoma were found, one each of solitary histiocytoma, multiple cutaneous reticulohistiocytosis and multicentric reticulohistiocytosis. One of the patients had polyarthritis and none of them had associated connective tissue disease nor malignancy. Conclusion: Reticulohistiocytosis may present as solitary or multiple lesions. It may be associated with severe arthritis and mimic rheumatoid arthritis. However, it may or may not be associated with connective tissue disease or malignancy.

背景：網狀組織細胞增多症是一種罕有的組織細胞增生症，多中心性網狀組織細胞增多症其表徵近似類風濕性關節炎。目的：報告香港網狀組織細胞增多症一系列病例並聚焦於臨床表現及疾病進程。取材及方法：檢索由二千零五年至二千零壹拾壹年香港衛生署轄下社會衛生科的病歷檔案並抽取有病理學確診的網狀組織細胞增多症資料。結果：三人確診而其中一人為獨立性網狀組織細胞增多症，一人為多發性網狀組織細胞增多症，一人為多中心性網狀組織細胞增多症，一人有多樣關節炎而沒有人有結締組織病或癌病。結論：網狀組織細胞增多症可表現為獨立或多個病變，既可顯生關節炎及相類似類風濕關節炎，亦可有或可無地併發為結締組織病或癌病。

Keywords: Multicentric reticulohistiocytosis, rheumatoid arthritis

關鍵詞: 多中心性網狀組織細胞瘤病，類風性濕關節炎