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Archive

Winter 2009, Vol. 17 No. 4

Hong Kong J. Dermatol. Venereol. (2009) 17, 181-189


Original Article

Efficacy and safety of pseudo-ceramide containing moisture cream in the treatment of senile xerosis

NM Luk 陸乃明, HC Lee 李孝治, KLE Hon 韓錦倫, K Ishida 石田耕一

Abstract
Objective: To study the efficacy and safety of a pseudo-ceramide containing moisture cream among Chinese patients with xerosis. Method: This was a single arm study with 30 elderly home residents recruited. After two-week wash out period, a pseudo-ceramide containing moisture cream were applied twice daily to the test areas (volar aspect of forearm and lateral aspect of calf) by nursing staff. The clinical symptoms, clinical xerotic severity scores and dermoscopic pictures were obtained before and after 3 weeks of treatment. The skin hydration and trans-epidermal water loss were measured before and at 1, 2 and 3 weeks after treatment commenced. Any adverse effect during the study was recorded. The acceptability of the test moisture cream was also enquired at the end of the study. Results: After 3 weeks of treatment with the moisture cream, there was a significant time-dependent improvement in skin hydration. The effect of the moisture cream on the trans-epidermal water loss (TEWL) was equivocal with a transient beneficial effect during the first two weeks but was not sustainable in the third week. On the clinical symptoms, there was a significant improvement in dryness, roughness and itch, but with no difference in the symptoms of tightness, scaliness, erosions and hotness. There was also a significant improvement in the clinical severity scores and dermoscopic appearance. No adverse event was reported. The moisture cream was well accepted by the subjects. Conclusion: A pseudo-ceramide containing moisture cream was able to increase skin hydration and might be able to decrease trans-epidermal water loss in elderly patient with xerosis. It improved some of the subjective symptoms of xerosis, the clinical xerotic severity score and dermoscopic appearance.