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Autumn 2007, Vol. 15 No. 3

Hong Kong J. Dermatol. Venereol. (2007) 15, 133-136


Case Report

Cutaneous Rosai-Dorfman disease: an uncommon cause of granulomatous inflammation

KM Lam 林嘉雯 and PCL Choi 蔡祥龍

Abstract
Rosai-Dorfman disease (RDD) is a benign idiopathic proliferative disorder. It commonly affects lymph nodes, but other organs can be involved. RDD limited to skin is rare. We report a 45-year-old Chinese man suffering from RDD. The first three skin biopsies revealed granulomatous inflammation. The diagnosis was made by the fourth skin biopsy, which showed a characteristic histology of large pale-staining histiocytes that exhibited emperipolesis and stained positive for S-100 protein.