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Archive

Spring 2007, Vol. 15 No. 1

Hong Kong J. Dermatol. Venereol. (2007) 15, 10-16


Review Article

A review on Hailey-Hailey disease

TS Cheng 鄭天錫

Abstract
Hailey-Hailey disease (HHD) is a rare autosomal dominant blistering skin disease first described in 1939. It is characterised by vesicular or crusted erosions on the neck and in intertriginous areas. Though it is known that the gene responsible for HHD is located on 3q21-q24, it is only recently found that the disease is a result of the mutations in the Ca2+ ATPase ATP2C1. A spectrum of mutations have been reported since the identification of the mutation. The disease not only causes itching, unpleasant smell, it might also lead to pain. Thus, the disease may cause significant impact on quality of life. A variety of modalities of treatment have been offered to the patients with various success. This paper reviews the literature to provide a current understanding of the disease. ((2007) 15, 10-16)