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Archive

Winter 2006, Vol. 14 No. 4

Hong Kong J. Dermatol. Venereol. (2006) 14, 189-195


Review Article

Use of enzyme immunoassay as treponemal screening test in syphilis diagnosis

WL Leung 梁偉蓮 and KM Kam 甘啟文

Abstract
Serological methods play a major role in the diagnosis and treatment monitoring of syphilis infection. With the development and commercial availability of well performing syphilis enzyme immunoassays (EIAs), many laboratories are switching from their traditional nontreponemal screening algorithm to new EIA treponemal screening strategy. Recent experiences have been gained on testing with different EIA antigens as well as amongst different at-risk populations e.g. pregnancy, HIV. This paper reviews these developments, evaluations and practices of treponemal EIAs and aims to provide an overview on its practical application for syphilis laboratory diagnosis in Hong Kong. (Hong Kong J. Dermatol. Venereol. (2006) 14, 189-195)