Table of Content

Archive

Autumn 2005, Vol. 13 No. 3

Hong Kong J. Dermatol. Venereol. (2005) 13, 141-148


Review Article

Advances in paediatric dermatology

CY Yeung 楊志強

Abstract
Significant progress has been made in understanding of the pathobiology of many dermatological syndromes in children, allowing more precise and prompt diagnosis. The identification of SPINK5 gene in Netherton syndrome and connexin defects in keratoderma illustrates the impact of the molecular biology in understanding the process of cornification. Recognition of at risk groups with congenital melanocytic naevi and vascular anomalies helps to intervene at early stage of the complications. Use of systemic corticosteroid, retinoids, azathioprine and methotrexate are now proved to be safe and effective for many dermatological conditions provided that proper ways of monitoring side effects are available.