Table of Content


Summer 2003, Vol. 11 No. 2

H.K. Dermatol. Venereol. Bull. (2003) 11, 68-72

Review Article

A review on human herpesvirus type 8 infection

PKS Chan 陳基湘 and RCW Chan 陳志偉

Human herpesvirus type eight (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV) is the most recently identified human herpesvirus. Over the last decade, many studies have focused on the epidemiology and disease association of this novel virus. It is aetiologically associated with Kaposi's sarcoma and some rare malignancies that are mainly found in AIDS patients. A link between HHV-8 and several diseases such as basal cell carcinoma, multiple myeloma and pemphigus has been suspected. However, convincing evidence is still lacking. In contrast to all previous known human herpesviruses, the prevalence of HHV-8 varies substantially with geographical location. Current data suggest that the principal route of transmission is also different between populations. While Kaposi's sarcoma is rare in Hong Kong, the limited available data provide some hints that this infection might be more prevalent in this locality than one would have expected.