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Archive

Spring 2003, Vol. 11 No. 1

H.K. Dermatol. Venereol. Bull. (2003) 11, 9-14


Review Article

Human papillomavirus infections

JYC Lo 羅懿之

Abstract
Human papillomavirus (HPV) infections are associated with a variety of benign and malignant conditions of the skin and mucous membranes. Of major clinical and public health significance is its relationship with cervical carcinoma. The pathogenetic mechanisms for HPV infection have gradually been elucidated, and the sequence of events in the initiation of carcinogenesis has been established. Laboratory diagnosis of HPV is mainly focused on the use of molecular techniques in cervical specimens for detection of HPV genotypes strongly associated with cervical carcinoma. Various treatment modalities for HPV infections are available, although none is distinctly superior. Prevention strategies are traditionally targeted on avoidance of infection via contact. Recent advances in vaccine development are promising in the prospect of eventual reduction of the disease burden of HPV infection.