Table of Content

Archive

Spring 2001, Vol. 9 No. 1

H.K. Dermatol. Venereol. Bull. (2001) 9, 4-9


Original Article

Ciclosporin Microemulsion for Severe Atopic Dermatitis: Experience on Adolescents and Adults in Hong Kong

HF Ho, LY Chong, KM Ho and WK Fung

Abstract
Ciclosporin microemulsion (Sandimmun Neoral ® ) is an oral formulation of ciclosporin with more consistent intestinal absorption. In this prospective, open study, ciclosporin microemulsion was used to manage adolescent and adult patients with severe refractory atopic dermatitis. Twenty-five patients participated (age range 12-34). Ciclosporin microemulsion was started at 3 mg/kg/day, slowly stepping up to a maximum of 5 mg/kg/day according to the response of the individual patient. The duration of treatment was 12 weeks with a further eight weeks of follow up. Ciclosporin microemulsion was found to be fast acting and effective in our patients: disease severity score decreased by 63%; extent of disease score decreased by 46%; pruritus score decreased by 77%. We concluded that ciclosporin microemulsion used as short course treatment was an effective therapy for severe refractory atopic dermatitis in adolescents and adults with acceptable side effects.