Current Issue
Spring/Summer 2025, Vol. 32 No. 1
Hong Kong J. Dermatol. Venereol. (2025) 32, 4-18
Original Article
Joinpoint regression analysis of incidence and mortality rates for superficial spreading malignant melanoma across diverse demographic characteristics and tumour attributes: a 22-year review of superficial spreading malignant melanoma
不同人口特徵與腫瘤屬性的淺表擴散型惡性黑色素瘤發病率與死亡率的連結點回歸分析：淺表擴散型惡性黑色素瘤22年回顧
Abstract
Background: In recent years, the incidence and mortality rates of superficial spreading malignant melanoma (SSMM) have significantly increased. However, comprehensive epidemiological studies examining these trends remain scarce. This study aims to explore changes in SSMM incidence and mortality over Twenty-two years. Methods: Data on SSMM patients were extracted from the SEER database, covering incidence and incidence-based mortality. Joinpoint regression analysis was used to calculate the Average Annual Percent Change (AAPC) and 95% confidence intervals (CI). Results: From 2000 to 2021, 131,235 SSMM cases were identified with an age-adjusted incidence rate of 6.98 (95% CI: 6.94-7.01) and an incidence-based mortality rate of 1.33 (95% CI: 1.31-1.34). Males accounted for 54.92% of cases, with 48.82% of patients under 60 years old. Predominantly, SSMM lesions were found on the limbs (46.64%), scalp and neck (14.9%), and trunk (38.47%). SSMM incidence increased significantly (AAPC=2.1%) throughout the study period, while mortality surged sharply from 2000 to 2012 (AAPC=19.9%) before stabilising. The trends varied by sex, age, race, and primary tumor site, with higher rates observed among older individuals, White patients, and those with tumors in sun-exposed areas. Conclusions: The findings reveal a notable increase in SSMM incidence and mortality, with variations across demographic and clinical subgroups. These insights can enhance our understanding of SSMM and support targeted healthcare interventions.
背景：近年來，淺表擴散型惡性黑色素瘤 (SSMM) 的發病率和死亡率都顯著增加。然而，檢視這些趨勢的全面流行病學研究仍然很少。本研究旨在探討22年來 SSMM 發病率和死亡率的變化。方法：從 SEER 資料庫中擷取 SSMM 患者的資料，涵蓋發病率和以發病率為基礎的死亡率。接合點回歸分析用於計算平均年度百分比變化 (AAPC) 和 95% 置信區間 (CI)。結果：從2000年到2021，共發現131,235例 SSMM 病例，經年齡調整後的發病率為6.98 (95% CI: 6.94-7.01)，發病死亡率為 1.33 (95% CI: 1.31-1.34)。男性佔54.92%，60歲以下的病患佔48.82%。SSMM 病變主要發生在四肢 (46.64%)、頭皮和頸部 (14.9%) 以及軀幹 (38.47%)。在整個研究期間，SSMM 的發病率顯著增加 (AAPC = 2.1%)，而死亡率則在2000 年至2012年間急速上升 (AAPC = 19.9%)，之後趨於穩定。趨勢因性別、年齡、種族和原發腫瘤部位而異，年長者、白人患者和腫瘤位於陽光曝曬部位者的發生率較高。結論：研究結果顯示 SSMM 發病率和死亡率顯著增加，不同人口和臨床次群體的情況也有差異。這些洞察力可增進我們對 SSMM 的了解，並支援有針對性的醫療照護干預措施。
Keywords: Incidence, Mortality, SEER, Superficial spreading malignant melanoma, Trends
關鍵詞: 發病率、死亡率、SEER、表淺擴散性惡性黑色素瘤、趨勢
