Table of Content

Current Issue

Summer 2021, Vol. 29 No. 2

Hong Kong J. Dermatol. Venereol. (2021) 29, 62-70


Review Article

A review of oral treatments for melasma

黃褐斑口服治療綜述

SYT Tan 陳瀅俐 and DCW Aw 胡政偉

Abstract
This article aims to evaluate current literature reporting on the efficacy and safety of oral agents in melasma management. An electronic search of publications via PUBMED database was conducted. The search only included clinical trials in the English language until 1 November 2019. This review is limited by small number of high-quality prospective studies each with small patient numbers. Significant heterogeneity in study design concerning study duration, concurrent treatments and outcome measures was present. Irrespective of melasma duration, oral tranexamic acid 500 mg daily appears to be a safe and effective treatment either as monotherapy or as an adjunct treatment.

本文旨在評估現有口服藥物在黃褐斑治療中的有效性和安全性的文獻報告。通過PUBMED數據庫對出版物進行了電子搜索,搜索僅包括截至2019年11月1日的英語臨床試驗。本綜述受限於少數高質量前瞻性研究內的患者人數皆很少。研究設計在研究持續時間、同步治療和結果測量方面存在顯著異質性。無論黃褐斑持續時間長短,或作為單一療法還是輔助療法,每天口服500毫克氨甲環酸似乎是一種安全而有效的治療方法。

Keywords: Dermatology, melasma, tranexamic acid

關鍵詞: 皮膚科、黃褐斑、氨甲環酸