Table of Content

Current Issue

Spring 2021, Vol. 29 No. 1

Hong Kong J. Dermatol. Venereol. (2021) 29, 26-31


Case Report

Oral malignant acanthosis nigricans associated with serous endometrial carcinoma: a case report and review of the literature

漿液性子宮內膜癌伴口腔惡性黑棘皮病的一宗病例報告暨文獻綜述

HK Ozden and D Bayramgürler

Abstract

Malignant acanthosis nigricans is a paraneoplastic cutaneous syndrome. Clinical findings such as tripe palms and mucocutaneous papillomatosis in atypical sites such as the oral mucosa are strong indicators of a visceral malignancy. We report on a rare case of oral acanthosis nigricans who presented with a 2.5-month history of diffuse hyperkeratotic verrucous papillomatous lesions in the entire oral mucosa which were symptomatic only when eating. Based on the clinical and histopathological findings, acanthosis nigricans with serous type endometrial carcinoma was diagnosed. However; the patient defaulted follow-up after the diagnosis and she died two months later.

惡性黑棘皮病是一種腫瘤伴生皮膚綜合症。臨床發現如牛胃掌和非典型部位(如口腔黏膜)的黏膜皮膚乳頭狀瘤症,是內臟惡性腫瘤的有力指標。我們報告了一個罕見的口腔黑棘皮病病例,患者整個口腔粘膜中有瀰漫性過度角化性疣狀乳頭狀病變,為時兩個半月,僅在進食時才有不適。根據臨床和組織病理學發現,最終被診斷為黑棘皮病伴隨漿液性子宮內膜癌。然而,該患者診斷後未有依時覆診,並在兩個月後身故。

Keywords: Endometrial carcinoma, malignant acanthosis nigricans, tripe palm

關鍵詞: 子宮內膜癌、惡性黑棘皮病、牛胃掌