Table of Content

Current Issue

Spring 2021, Vol. 29 No. 1

Hong Kong J. Dermatol. Venereol. (2021) 29, 26-31

Case Report

Oral malignant acanthosis nigricans associated with serous endometrial carcinoma: a case report and review of the literature


HK Ozden and D Bayramgürler


Malignant acanthosis nigricans is a paraneoplastic cutaneous syndrome. Clinical findings such as tripe palms and mucocutaneous papillomatosis in atypical sites such as the oral mucosa are strong indicators of a visceral malignancy. We report on a rare case of oral acanthosis nigricans who presented with a 2.5-month history of diffuse hyperkeratotic verrucous papillomatous lesions in the entire oral mucosa which were symptomatic only when eating. Based on the clinical and histopathological findings, acanthosis nigricans with serous type endometrial carcinoma was diagnosed. However; the patient defaulted follow-up after the diagnosis and she died two months later.


Keywords: Endometrial carcinoma, malignant acanthosis nigricans, tripe palm

關鍵詞: 子宮內膜癌、惡性黑棘皮病、牛胃掌