Table of Content

Current Issue

Spring 2020, Vol. 28 No. 1

Hong Kong J. Dermatol. Venereol. (2020) 28, 5-10


Original Article

Effectiveness of application of serum and cream containing combination of tranexamic acid, galactomyces ferment filtrate, niacinamide, and alpha arbutin using layering technique in melasma

含傳明酸、半乳桿菌發酵濾液、煙酰胺和甲型熊果素結合的精華和乳膏層疊式塗抹在黃褐斑的應用效果

AI Anwar, S Budhiani, A Seweng, A Arimuko, L Norawati, S Veronica

Abstract

Objective: This research aimed to determine the effect of tranexamic acid 3% in combination with several brightening agents including Galactomyces ferment filtrate 2%, niacinamide 4% and alpha arbutin 2%, in melasma treatment. Methods: This was a multi-centre trial which was held Hasanuddin University hospital in Makassar, South Sulawesi, Indonesia and Gatot Soebroto Central Army hospital in Jakarta, Indonesia. A total of 66 patients with epidermal and/or mixed-type melasma were instructed to apply tranexamic acid in combination serum containing 3% tranexamic acid, 2% Galactomyces ferment filtrate, 4% niacinamide, and 2% alpha-arbutin, followed by cream with the same content (layering technique) for four weeks. The clinical appearance was assessed using melasma severity score (MSS) while skin analyser Janus Facial Analyses System® was used to assess the spot ultraviolet (UV) (parameter for dermal hyperpigmentation) and spot polarised (PL) (hyperpigmentation in the epidermis). The MSS score, spot UV and spot PL were measured at baseline and at follow up every two weeks and four weeks. Results: MSS score showed significant reduction in week 2 (1.33%) and week 4 (1.47%) compared to baseline (1.65%). There was a significant decrease of spot UV value from baseline (22.6%) compared to week 2 (20.1%) and week 4 (19.8%). However, no significant differences in spot PL value from baseline to week 2 and week 4. Conclusion: Application of combination of tranexamic acid 3% with Galactomyces ferment filtrate 2%, niacinamide 4% and alfa arbutin 2% in serum and cream preparation using layering technique was effective in treating melasma.

目的:本研究旨在確定3%傳明酸混合數種增白劑(包括2%半乳發酵濾液、4%煙酰胺和2%甲型熊果素)的組合用來治療黃褐斑的效果。方法:這是一項多中心臨床試驗,在印度尼西亞南蘇拉威西省望加錫的哈桑努丁大學醫院和印度尼西亞雅加達的加托特.索布羅託中央軍醫院進行。總共66名表皮或混合型黃褐斑患者,按指示先塗抹含有3%傳明酸、2%半乳發酵濾液、4%煙酰胺和2%甲型熊果素結合的精華,再重複塗多一層相同成分的乳劑,持續四個星期。我們使用黃褐斑嚴重度分數來評估臨床外觀,同時使用皮膚分析儀Janus面部皮膚檢測系統®評估點紫外線(真皮層色素沉著過度的參數)和點極化(表皮色素沉著過度)。分別在基線、第二周和第四周跟進時,測量黃褐斑嚴重度分數、點紫外線和點極化。結果:與基線(1.65%)相比,黃褐斑嚴重度分數評分在第二週(1.33%)和第四週(1.47%)顯著降低。第二週(20.1%)和第四週(19.8%)的點紫外線值亦較基線(22.6%)低。反之,基線到第2周和第4週的點極化值無顯著差異。結論:將3%傳明酸與2%半乳發酵濾液、4%煙酰胺和2%甲型熊果素結合的精華和乳膏層疊式塗抹能有效治療黃褐斑。

Keywords: Alfa arbutin, Galactomyces ferment filtrate, melasma, niacinamide, tranexamic acid

關鍵詞: 甲型熊果素、半乳桿菌發酵濾液、黃褐斑、煙酰胺、傳明酸