Table of Content

Current Issue

Summer 2019, Vol. 27 No. 2

Hong Kong J. Dermatol. Venereol. (2019) 27, 59-67


Original Article

Linking the PASI of sufferers from moderate and severe psoriasis to an increase of carotid intima-media thickness: a cross-sectional study

中重度銀屑病患者的銀屑病皮損面積和嚴重度指數(PASI)與頸動脈內膜中層厚度增加的相關聯橫斷面研究

A Martinez-Lopez, L Salvador-Rodriguez, A Rodriguez-Tejero, G Blasco-Morente, J Tercedor-Sanchez, S Arias-Santiago

Abstract

Psoriasis is a multsystemic disease which has been related with comorbidities such as metabolic syndrome and arteriosclerosis through a psoriasis-related inflammatory chronic state. In order to assess the relationship of psoriasis with carotid intima-media thickness (IMT), 100 moderate-to-severe psoriatic patients were studied. Increased PASI score was associated with a higher IMT. Additionally, a higher IMT was observed with the increasing of erythrocyte sedimentation rate. In conclusion, patients with moderate-to-severe psoriasis are at higher risk of an increased IMT.

銀屑病是一種多系統的疾病,因其慢性的炎症性狀態,已發現相關的合併症包括代謝綜合徵和動脈硬化。為了評估銀屑病與頸動脈內膜中層厚度(IMT)的關係,我們對100名中度至重度銀屑病患者進行了研究,發現銀屑病皮損面積和嚴重度指數評分高者相應地頸動脈內膜中層厚度較厚。此外,頸動脈內膜中層厚度較厚者亦觀察到有紅細胞沉降率昇高。總括來說,中重度銀屑病患者有著較高的頸動脈內膜中層增厚風險。

Keywords: Atherosclerosis; chronic inflammation; intima-media thickness; psoriasis; TNF-alpha

關鍵詞: 動脈粥樣硬化、慢性炎症、內膜中層厚度、銀屑病、甲型腫瘤壞死因子