Table of Content

Archive

Spring 2017, Vol. 25 No. 1

Hong Kong J. Dermatol. Venereol. (2017) 25, 5-12


Original Article

Obese/overweight and the risk of acne vulgaris in Chinese adolescents and young adults

華裔青少年和青壯年中的肥胖/超重與尋常痤瘡的風險

LY Lu 陸凌怡, HY Lai 賴慧穎, ZY Pan 潘展硯, ZX Wu 吳忠孝, WC Chen 陳文傑, Q Ju 鞠強

Abstract

Background: An association between obese/overweight and acne vulgaris has long been postulated, but with controversial results. Aim: This study was designed to investigate the relationship between acne vulgaris, body mass index (BMI), and family history of related metabolic disorders in Chinese. Methods: We conducted a case-control study of risk factors for acne in a Chinese Han population aged 10 to 25 years attending outpatient departments in PR China. A total of consecutive 364 patients with acne were recruited, while 295 non-acne patients or healthy subjects served as controls. Results: The mean BMI was higher in moderate to severe acne patients (Pillsbury grading scale, grades 3 and 4) (21.86±2.83 kg/m2) than controls (20.22±2.43 kg/m2) (P<0.001). Moderate to severe acne was positively associated with overweight and obesity in people aged 18-25 years, with a more pronounced effect in women [Odds ratio (OR) 14.526, 95% confidence interval (CI) 2.961-71.272, P<0.001] than in men (OR 3.528, 95% CI 1.553-8.014, P=0.002). Body mass index in patients with thorax-back lesions were higher (22.30±2.57 kg/m2) than patients without thorax-back lesions (20.68±2.23 kg/m2) (P<0.001) and the relationship between thorax-back acne and overweight was observed (OR 4.480, 95% CI 2.182-9.196, P<0.001). Presence of family history of metabolic disorders such as hypertension (OR 3.511, 95% CI 1.977-6.233, P<0.001), diabetes (OR 2.697, 95% CI 1.565-4.647, P<0.001), overweight and obesity (OR1.844, 95% CI 1.242-4.407, P=0.032) were also found to be associated with increased acne severity. Conclusions: Obese/overweight in women aged 18-25 years with severe acne and family history of metabolic disorders could be risk factors of acne in Chinese acne patients.

背景:肥胖/超重和尋常痤瘡的關聯早已被假定,可是結果仍存有爭議。目的:本研究旨在調查華裔中的尋常痤瘡與身體質量指數及相關代謝疾病家族史的關係。方法:我們在中國的一個門診部門對10-25歲的華裔漢族進行了痤瘡危險因素的病例對照研究。總共招募了364名痤瘡患者,另295名非痤瘡患者或健康人仕作為對照。結果:中度至重度痤瘡患者(皮爾斯博瑞分級量表,3級和4級)(21.86±2.83公斤/平方米)的平均身體質量指數高於對照組(20.22±2.43公斤/平方米)(P<0.001)。中度至重度痤瘡在18-25歲人群組與超重和肥胖呈正相關,當中的女性更為顯著〔比值比(OR)14.526,95%置信區間(CI)2.961-71.272,P<0.001〕,大幅拋離男性(OR 3.528,95% CI 1.553-8.014,P=0.002)。胸部背部發病者的身體質量指數(22.30±2.57公斤/平方米)高於沒有胸部背部發病的(20.68±2.23公斤/平方米)(P<0.001),當中亦不難察覺胸部背部痤瘡與超重之間的關係(OR 4.480,95% CI 2.182-9.196, P<0.001)。代謝疾病的家族史如高血壓(OR 3.511,95% CI 1.977-6.233,P<0.001)、糖尿病(OR 2.697,95% CI 1.565-4.647,P<0.001),超重和肥胖(OR1.844 ,95% CI 1.242-4.407,P=0.032)等都與較重的痤瘡嚴重性相關。結論:代謝疾病家族史及18-25歲嚴重痤瘡女患者的肥胖/超重可能是華裔痤瘡患者的危險因素。

Keywords: Acne vulgaris, BMI (body mass index), Chinese adolescent and young adults, family history of metabolic disorders, risk factors

關鍵詞: 尋常痤瘡、身體質量指數、華裔青少年和青壯年、代謝疾病家族史、風險因素