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Winter 2015, Vol. 23 No. 4

Hong Kong J. Dermatol. Venereol. (2015) 23, 191-196


Case Report

A case series of cutaneous Penicillium marneffei infection with dissemination

皮膚馬爾尼菲青黴菌感染與播散的病例系列

YC Weng 翁毓菁, JL Shen 沈瑞隆, CS Yang 楊啟順, WH Li 李文豪

Abstract

Penicilliosis is an infection caused by Penicillium marneffei, which is an opportunistic fungal pathogen endemic in areas such as Southeast Asia. It is usually found in patients infected with human immunodeficiency virus (HIV). P. marneffei is present in soil and is also associated with bamboo rats. Patients with AIDS are particularly susceptible to infection. Thus, penicilliosis is an important differential diagnosis in immunocompromised patients with an acneiform eruption. Early detection and diagnosis can improve the outcome for these patients. We report a case series of two HIV patients with disseminated P. marneffei, who presented with acneiform eruptions, and discuss the relevant literature.

青黴菌病是一種由馬爾尼菲青黴菌引起的感染,該真菌為機會性真菌病原體,流行地區包括東南亞國家,並常見於愛滋病病毒感染者。馬爾尼菲青黴菌一般存在於土壤中,竹鼠體內亦有發現。愛滋病患者特別容易受其感染,所以在免疫功能低下患者的痤瘡狀發疹中,青黴菌病是一個重要的鑑別診斷。透過早期的檢測和診斷,患者病情可得到理想改善。我們報告一系列兩名愛滋病病毒感染者併發播散性馬爾尼菲青黴菌感染,表現為痤瘡狀發疹,並討論相關文獻。

Keywords: Acneiform eruptions, AIDS, human immunodeficiency virus, infection, Penicillium marneffei

關鍵詞: 痤瘡狀發疹、愛滋病、人類免疫力缺乏病毒、感染、馬爾尼菲青黴菌